Hyperoxia causes MIR-34a-mediated injury via angiopoietin-1 in neonatal lungs

Abstract

Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1.