Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

Abstract

Oxidative damage is an important contributor to the morphological and the functional changes in the development of osteoporosis. In this reported work, the use of cerium oxide (CeO2) nanoparticles as a potential therapeutic agent for osteoporosis is explored. By using the primary osteoblasts (OBs) exposed to hydrogen peroxide (H2O2), it is shown that the CeO2 nanoparticles relieve the H2O 2-induced oxidative damage. The protective effects of the CeO 2 nanoparticles were because of a reduction in the reactive oxygen species (ROS). The level of the antioxidant enzymes was increased after treatment with the CeO2 nanoparticles in the OBs exposed to H 2O2. Moreover, the cell apoptosis rate was decreased after treatment with the CeO2 nanoparticles. The CeO2 nanoparticles protect the OBs against the H2O2-induced oxidative damage, suppression of the antioxidant enzymes depletion and cell apoptosis via its ROS scavenging mechanism. The findings suggest that the CeO2 nanoparticles may have a potentially therapeutic value for the diseases related to the ROS. © 2014 The Institution of Engineering and Technology.