Regulation of Smad Function by Phosphorylation

  • Yakymovych I
  • Souchelnytskyi S
N/ACitations
Citations of this article
7Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Phosphorylation is a dynamic and reversible post-translational modification which has a strong impact on structural features of proteins. All Smad proteins have been reported as phosphoproteins. Phosphorylation of receptor-activated Smad proteins by type I receptors initiates TGF-β family signaling. Phosphorylation of Smads by a number of other kinases is a mechanism of cross-talk between Smads and other signaling pathways. Smad phosphorylation initiates a cascade of protein-protein and protein-DNA interactions, and affects localization of Smads. This chapter reviews the role of phosphorylation in Smad signaling

Cite

CITATION STYLE

APA

Yakymovych, I., & Souchelnytskyi, S. (2007). Regulation of Smad Function by Phosphorylation. In Smad Signal Transduction (pp. 235–252). Springer Netherlands. https://doi.org/10.1007/1-4020-4709-6_12

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free