Investigating ionic effects applied to water based organocatalysed aldol reactions

13Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C 2-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was always a superior medium to salt solutions though some correlation to increasing anion size and depression in enantiomeric excess could be observed. Additionally, the complete inhibition of catalyst activity observed when employing tap water could be alleviated by the inclusion of ethylenediaminetetraacetate (EDTA) into the aqueous media prior to reaction initiation. Extension of these reaction conditions demonstrated that these ionic effects vary on a case-to-case basis depending on the ketone/aldehyde combination. © 2011 by the authors; licensee MDPI, Basel, Switzerland.

Cite

CITATION STYLE

APA

Delaney, J. P., & Henderson, L. C. (2011). Investigating ionic effects applied to water based organocatalysed aldol reactions. International Journal of Molecular Sciences, 12(12), 9083–9094. https://doi.org/10.3390/ijms12129083

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free