Antibiotic susceptibility of ESBL-producing urinary isolates at a Tertiary Care Hospital in Tiruchirappalli South India

Abstract

The aim of this study was to obtain data on susceptibility patterns of bacterial pathogens from patients who attended the CSI Mission General Hospital, in Tiruchirappalli, South India from June 2004-June 2005. During the one-year period of study, the most prevalent etiological agent was Escherichia coli (44.02%), followed by Klebsiella pneumoniae (14.53%) and other species of Enterobacteriaceae (41.45%). These isolates were susceptible to many antimicrobial agents, but those that produced extended spectrum β-lactaniases (ESBLs) were resistant to most of the antimicrobials. Of all the Enterobacteriaceae tested over a period of 6 months, 236 (25.2%) among 936 were ESBL producers. ESBL production was determined by double disc synergy test. The antibiograms of the ESBL and non ESBL-producers were also compared. Many of the ESBL producers were found to be multidrug-resistant.