Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

Abstract

Inflammation is a common feature of aging tissues, being involved in most, if not all, age-related diseases. The origin of a low-grade inflammation state in aging (inflammaging) is multifactorial and may involve changes in body composition, immunosenescence, autophagy, microbiota modification and loss of proteostasis. The heat shock response pathway (HSR, and HSP70 expression) plays an important role as a mechanism of resolution of inflammation and proteostasis control. In this review, we sought to discuss the mechanisms that may lead to inflammaging, and the importance of the HSP70 in this process. Besides, we also discuss how physical exercise, particularly resistance training, can improve the HSR and the inflammatory balance of elderly people.