The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation

Abstract

The role of HSSTnT in cardiac muscle regulation is unknown. Results: HSSTnT isoforms regulate Ca2+ sensitivity and maximal force of contraction in skinned fibers in a different fashion compared with HCTnT3. Conclusion: HSSTnT isoforms despite being homologues of CTnT display distinct functional properties. Significance: The HSSTnT isoforms, when expressed in the heart, would play a specific role in desensitizing the myofilament toCa2+. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.