The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite

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Abstract

The antibiotic micrococcin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.

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Rogers, M. J., Cundliffe, E., & McCutchan, T. F. (1998). The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite. Antimicrobial Agents and Chemotherapy, 42(3), 715–716. https://doi.org/10.1128/aac.42.3.715

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