Abstract
Cancer persister cells remain a significant barrier to effective anti-cancer therapy. We found that melanoma persister cells undergo a reversible reprogramming of mRNA translation. A subset of mRNAs, harboring N6-methyladenosine in their 5ʹ-untranslated regions, is translationally up-regulated in an eIF4A-dependent manner. Targeting eIF4A prevents the emergence of resistant clones.
Author supplied keywords
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
Already have an account? Sign in
Sign up for freeCite
CITATION STYLE
APA
Shen, S., & Sun, X. (2020, May 3). Emerging role of mRNA epitranscriptomic regulation in chemoresistant cancer cells. Molecular and Cellular Oncology. Taylor and Francis Ltd. https://doi.org/10.1080/23723556.2020.1728467
Readers' Seniority
Readers' Discipline
