Cerebral monitoring and surveillance using high-resolution functional optical imaging

Abstract

Near-infrared (NIR) optical techniques, using large-area sensing arrays that provide for transcranial measures of cortical function, are finding increasing use for functional assessment of brain activity. In this chapter, we review current capabilities of these methodologies and describe their application to an in vivo large animal model, Bonnet macaque, for the purpose of imaging hemodynamic responses to clinically significant events, including detection of cerebral ischemia and hemorrhage. The described methodology outlines the technology and method of high-density diffuse optical tomography (DOT), as explored using recently developed analysis resources whose accuracy is independently validated. Also discussed are solutions to commonly encountered problems related to data collection and analysis.