3-O-sulfation synthesizes sulfatide in the galactose moiety of galactosylceramide. Sulfatide is expressed in many organs such as the gastrointestinal tract, trachea, kidney, and central nervous system. Influenza A virus binds not only to glycoconjugates terminally containing sialic acid as a viral binding receptor but also to sulfatide not containing sialic acid. On the surface of infected cells, the envelope glycoprotein hemagglutinin of influenza A virus interacts with sulfatide. This interaction enhances the nuclear export of viral ribonucleoprotein complexes, resulting in efficient progeny viruses. Inhibiting this interaction would be a new potent anti-influenza drug that suppresses the progeny virus production in the infected cells.
CITATION STYLE
Takahashi, T., Kurebayashi, Y., & Suzuki, T. (2022). Functional Analysis of Sulfatide in Influenza A Virus Infection and Replication. In Methods in Molecular Biology (Vol. 2556, pp. 97–122). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2635-1_9
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