Tolerogenic antigen presenting cells (APC), primarily dendritic cells (DC), are essential to the induction and maintenance of immunologic tolerance in clinical transplantation. They induce the differentiation of CD8+ T suppressor (Ts) and CD4+ T regulatory (Treg) or anergic cells, which prevent transplant rejection maintaining a state of quiescence. Tolerogenic APC express high levels of inhibitory receptors such as Immunoglobulin-like transcript (ILT)3 and 4 which inhibit the effector function of T cells that recognize HLA-peptide complexes on APC. Here, we describe the methods for detection of tolerogenic APC induced by allospecific Ts/Treg cells. © Springer Science+Business Media, LLC 2013.
CITATION STYLE
Vlad, G., & Suciu-Foca, N. (2013). Tolerogenic dendritic cells and induction of T suppressor cells in transplant recipients. Methods in Molecular Biology, 1034, 359–371. https://doi.org/10.1007/978-1-62703-493-7_23
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