Cortical spreading depression as a site of origin for migraine: Role of CGRP

86Citations
Citations of this article
142Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Premise: Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. Problem: One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored. However, recent data suggest several potential vascular and neural connections between calcitonin gene-related peptide and cortical spreading depression. Conclusion: This review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.

Cite

CITATION STYLE

APA

Close, L. N., Eftekhari, S., Wang, M., Charles, A. C., & Russo, A. F. (2019, March 1). Cortical spreading depression as a site of origin for migraine: Role of CGRP. Cephalalgia. SAGE Publications Ltd. https://doi.org/10.1177/0333102418774299

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free