A major challenge in single or panel of biomarker discovery and validation is the inherent biological complexity underlying disease heterogeneity and inconsistent responses to treatment. Moreover, the lack of standardization in the sampling, processing, and storage of biological fluids such as plasma and serum disrupts the discovery and validation of blood-based biomarker tests in preclinical and clinical settings. This chapter presents a reproducible sample collection and handling procedure that aims to enhance analyte stability and ensure compatibility with the corresponding multiplex biomarker profiling platforms. The importance of defining bio-sample acquisition and processing, study design, and profiling platform guidelines for blood-based biomarker measurements is paramount for the success of personalized healthcare strategy and development of companion diagnostics.
CITATION STYLE
Guest, P. C., & Rahmoune, H. (2017). Blood Bio-Sampling procedures for multiplex biomarkers studies. In Methods in Molecular Biology (Vol. 1546, pp. 161–168). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6730-8_12
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