Benefit effect of ethanolic extract of Bay leaves (Laura nobilis) on blood sugar level in adult diabetic rats induced by alloxan monohydrate

Abstract

In the present study, the effect of Bay leave ethanolic extract on blood glucose, insulin level, lipid profile, liver and kidney function and body weight in type 2 diabetic rats were investigated. Forty albino male rats(250-300) grams were divided into four groups (10 rats for each), first group treated with distilled water and served as control, second group treated with 200 mg\kg of Laura nobilis alcoholic extract, third group served as positive diabetic and the fourth group was served as diabetic and treated with 200 mg\kg b. w of alcoholic extract of Laurus nobilis, all groups were treated orally, the following results were evaluated in diabetic rats, fasting blood glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL),alanine aminotransferase (ALT),aspartate aminotransferase (AST),alkaline phosphatase (ALP), B. urea and s. creatinine levels were significantly increased while high density lipoprotein (HDL) and body weight significantly decreased as compared to control rats, after 30 days of treating by200 mg\kg b.w alcoholic extract of Bay leave there was significant decrease in fasting blood glucose and significant increase in fasting insulin level, also there was significant decrease in TG, TC, LDL, VLDL, ALT, AST, ALP, B. urea and s. creatinine level, while HDL and body weight increased in diabetic groups compared to control not treated groups.