Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently (30 of the patients each year) and it is associated with significant morbidity. This paper summarizes the current information regarding pathogenesis, definitions, management, and exploratory therapies in DUs associated with SSc. Copyright © 2010 Elena Schiopu et al.
Schiopu, E., Impens, A. J., & Phillips, K. (2010). Digital ischemia in scleroderma spectrum of diseases. International Journal of Rheumatology. https://doi.org/10.1155/2010/923743