Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.
CITATION STYLE
Kiernan, K., & MacIver, N. J. (2021, January 29). The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2020.622468
Mendeley helps you to discover research relevant for your work.