Ribosome-inactivating and related proteins

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Abstract

Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition, there is still not a uniform nomenclature or classification existing for RIPs. In this review, we give the current status of all known plant RIPs and we make a suggestion about how to unify those RIPs and RIP related proteins that cannot be classified as type 1 or type 2 RIPs.

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Schrot, J., Weng, A., & Melzig, M. F. (2015). Ribosome-inactivating and related proteins. Toxins, 7(5), 1556–1615. https://doi.org/10.3390/toxins7051556

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