Modern Application of Fish Oil

Abstract

Favorable characteristics and confronting problems in developing the modern application of fish oil are reviewed. In order to expand the utilization of fish oil, daily and highly consumed linoleic acid and saturated fatty acids must be replaced in part by icosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) concentrated fish oil, keeping the total lipid consumption at the level of modern Japan. For this purpose, technology in modifying lipids including enzymatic synthesis of EPA and DHA rich simple lipids as well as phospholipids is considered to be impelled. 1•@‚Í ‚ ¶ ‚ß ‚É "ModernAp Plication of Marine Oils"‚AE 'è ‚µ‚½ƒZ ƒ~ƒi •[ ‚ª4"ú ŠÔ‚É‚í ‚½‚Á‚ăJƒi ƒ_‚Ì ƒI ƒ"ƒ^ƒŠ ƒI •B‚ÅŠJ•Ã ‚³ ‚ê ‚é•BŽå•Ã‚ÍAOCS(ƒA ƒ• ƒŠƒJ-û ‰» Šw‹¦ ‰ï)‚Å,-ˆ "N‚Ì5OEŽ6"ú ‚©‚ç9"ú ‚Ü‚Å‚Ì-\ 'è ‚¾‚» ‚¤‚Å‚ ‚é •B ‚±‚ê ‚Í ‰¢ •Ä‚ª •H•i ‚Ö‚Ì ‹›-û ‚Ì-{Ši "I-˜-p ‚ð ‚ ‚´‚·ˆÓ‹C‚´‚·‚´‚·ˆÓ‹C•ž ‚Ý‚ðŽ¦ ‚·ˆê‚·ˆê-á ‚Å‚ ‚ë ‚¤•B ƒAƒ• ƒŠ ƒJ ‚ł͈ê‚Å‚Íˆê •ð "N(1989"N9OEŽ15 "ú)‚É ‹›-û ‚Ì •… "Y-û ‚È ‚ç‚Ñ‚É•" •ª •… "Y-û‚ªFDA(˜A-M •H•i •E ˆã-ò•i ‹Ç)‚ÌGRAS(Generally Recognized as Safe;‚· ‚È‚í ‚¿ˆê‚¿ˆê "ʂɈÀ'S ‚AE "F ‚ß ‚ç‚ê ‚é•¨ Ž¿)"F 'è ‚ð Žó‚¯ ‚½1),2)•B‚Ü‚½•ð"N(1990"N10OEŽ29"ú)‚à ‚ ‚ç‚ä ‚é OE`'Ô‚Ì ‹›-û‚ªGRAS"F 'è ‚ðŽó‚¯3),‚¢ ‚ae‚¢ ‚ae‹›-û‚Ì •H •i ‚Ö‚Ì-˜-p ‚ª-{Ši ‰»‚µ‚‚‚ ‚é•B•Ü ‚µ‚à ‚±‚ê ‚AE 'OOEサ‚Ä ƒCƒMƒŠƒX‚â ƒf ƒ"ƒ}•[ ƒN‚ð ‚Í ‚ ¶‚ ‚AE ‚· ‚é ƒˆ•ƒˆ•[ ƒ• ƒbƒp5‚© •' ‚AE ƒAƒ• ƒŠ ƒJ,ƒ` ƒŠ‚Ì ‹¤ "¯ ‚Å-¢•… "Y‹›-û‚ð "Y‰Á ‚µ‚½ƒ}•[ ƒK ƒŠƒ"‚Ì ŽŽ•ì ‚AE '™ ' ŽŽOE±,Š¯ "\ •] ‰¿ ‚ª •s ‚í ‚ê ‚½4)•B‚¢ ‚-‚¢ ‚-‚Í ƒTƒ‰ ƒ_-û‚â "÷•» •i ‚Ö‚Ì "Y‰Á ŽŽOE±‚à•s ‚í ‚ê ‚é ‚± ‚AE ‚É‚È ‚é‚Å‚ ‚ë ‚¤•B•¡ ‚Ü‚Å‹›-û‚Ì • ¶ ŽY‚AE-˜-p ‚ÉŠÖ‚µ‚Ä‚Í ‚í ‚ª •' ‚Ɉê "ú‚Ì '· ‚ª ‚ ‚Á‚½‚ª,‚± ‚Ì ‚ae ‚¤‚ɉ¢ •Ä‚É‚¨‚¯Ä‚É‚¨‚¯ ‚é•… ŽY-û Ž‰ ‚ÉŠÖ ‚· ‚éOE¤ ‹ † ‚Ì Šˆ"Šˆ"-‰» ‚Í,•Á "ï ŽÒ‚Ì ‹› ‚É'Î ‚· ‚éOE'•NƒC ƒ• •[ ƒW ‚ÉOE¡ˆø ‚³ ‚ê ‚Ä•¡ OEã‚Ü‚· ‚Ü‚· ‰Á '¬ ‚³ ‚ê ‚é-l 'Š ‚ð'ae ‚µ ‚Ä‚« ‚Ä‚¢ ‚é•B •Å‹ß,‚í ‚ª •' ‚Å‚ÍSCRC-2738(Alteromonus‚Ì1 Ží)5),6)‚â20-17(Mortierella alpina)7),8)‚ð-p ‚¢ ‚Ä EPA‚ð • ¶ ŽY‚· ‚é‹Z •p ‚ª ŠJ"-‚³ ‚ê,‚AE ‚-‚É•' "à ‚Å'½‚-‚Ì '•-Ú‚ð•W‚ß‚Ä‚¢ ‚é•B ‚±‚ê ‚ç‚Ì "÷• ¶ •¨ ‚ª ŽY • ¶ ‚· ‚é•‚ "x•s-O ˜a Ž‰-bŽ_(HUFA)‚Í,'g •¬‚ª ‹›-û ‚É"ä ‚× 'P •ƒ ‚Å‚ ‚é ‚± ‚AE ‚© ‚ç•s-v ‚ÈŽ‰-b Ž_‚ð •oe‚-‚± ‚AE ‚ª ‹›-û ‚ae ‚è ‚à-e ˆÕ‚Å‚ ‚è,‚µ ‚©‚àSCRC-2738Š" ‚Å‚ÍHUFA‚ð • ¶-• Šˆ•Šˆ•« ‚Ì "ñ•í ‚É•‚ ‚¢ ƒŠƒ"Ž‰ Ž¿‚Ì OE`'Ô‚Å"¾‚ç‚ê ‚é"™-˜ "_‚ª '½‚¢•B ‚Ü ‚½,OEã •q ‚Ì ‚ae ‚¤‚È‹› •L ‚â'… •F ‚Ì •S"z ‚ª •-‚È‚¢ ‚± ‚AE,ƒZ ƒg ƒOE ƒ"Ž_‚â ƒGƒ‹ ƒJŽ_(•S Ž¾ Š³ ‚Ì OE´ˆö)‚ð ŠÜ‚Ü‚È‚¢ ‚AE ‚¢ ‚Á‚½ "_ ‚É‚à-D ‚ê,ŽÀ-p ‰» ‚Ö‚Ì Šô‚‚©‚Ì-â'è "_ ‚³ ‚¦ ‰ð OEˆ‚· ‚ê ‚Î, ‚AE‚-‚Ɉã-ò•i ‚Ö‚Ì-˜-p ‚ÉŠÖ‚µ‚Ä‚Í •¡ OEã ‹É ‚ß‚Ä-L-] ‚AE ‚¢ ‚¦ ‚é•B ‚µ‚©‚µ,‹@ "\ •« •H•i(-ò-±•s •-‚AE‚Ì •®• ‡ •« ‚ð •} ‚éˆÓ-¡ ‚©‚畽•¬2"N11OEŽˆÈN11OEŽˆÈ •~ ‚Í "Á'è •ÛOE'•H•i ‚AE OEÄ ‚Ô‚± ‚AE‚É ‚È ‚Á‚Ä‚¢ ‚é)‚Ö ‚Ì-˜-p ‚ÉŠÖ‚µ‚Ä‚Í ‹› ‚É'Î ‚· ‚éOE'•NƒCƒ• •[ ƒW,DHA‚ð ŽY • ¶ ‚· ‚é"÷• ¶ •¨ ‚ª OE© ‚ ‚½‚ç‚È ‚¢ ‚± ‚AE,‚Ü ‚½ ‰¿ Ši ‚Ì "_‚©‚ç‚¢ ‚Á‚Ä‚à"-•ª ‚Ì ŠÔ‚Í ‹›-û‚Ì-D ˆÊ‚Í •ö ‚ê ‚» ‚¤ ‚É‚È‚¢ •B ‚AE‚-‚ɉ¢ •Ä‚Å‚Í ‚â ‚â'Z-• "I ‚AE‚à‚¢ ‚¦ ‚é‚Ù‚Ç"‹› "ñOE'•N"‚Ì ƒCƒ• •[ ƒW ‚ª ‹-‚-9),"÷ • ¶ •¨ OE¹HUFA‚Í •H•i ‚Ö-˜-p ‚³ ‚ê ‚É‚-‚¢ •ó ‹µ ‚É‚ ‚é ‚AE ‚¢‚¦ ‚ae‚¤•B 2•@‚í ‚ª •' ‚É ‚¨‚¯‚¨‚¯ ‚é ‹›-û ‚Ì-˜-p ‚Ì OE»•ó •º ˜a63"N ‚Ì "_-Ñ •… ŽY •È ‚Ì "• OEv ‚É ‚ae‚é ‚AE •…ŽY-û Ž‰ ‚Ì 'S •' "à • ¶ ŽY‚Í48.6-oet‚Å ‚ ‚è,‚± ‚ê ‚Í 'S •¢ ŠE‚Ì32.7%‚É "-‚½‚é•B ‚í ‚ª •' ‚Ì ‹›-û‚Ì-A •o ‚Í34.7-oet,•' "à•ª ‚Í13.9-oet‚Å ‚ ‚è,‚» ‚Ì ‚¤ ‚¿•Á"ï ‚³ ‚ê ‚½‚à‚Ì ‚Í10.8-oet‚AE ‚Ý‚È‚³ ‚ê, 159