Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults

10Citations
Citations of this article
57Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to fill this gap. The gut resistomes are characterized by a bimodal distribution driven by E. coli composition. The typical profile of the gut resistome differs significantly between adults and infants, with the latter distinguished by higher gene and plasmid abundances. However, the predominant antibiotic resistance genes (ARGs) are the same. Antibiotic treatment reduces bacterial diversity and increased ARG and plasmid abundances in both cohorts, especially core ARGs. The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics and the impact of antibiotic treatment across age groups.

Cite

CITATION STYLE

APA

Li, X., Brejnrod, A., Thorsen, J., Zachariasen, T., Trivedi, U., Russel, J., … Sørensen, S. J. (2023). Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-44289-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free