Separation, interconversion, and insecticidal activity of the cis- and trans-isomers of novel hydrazone derivatives

Abstract

A series of cis- and trans-isomers of hydrazone derivatives were separated and analyzed through HPLC with diode-array detection and HPLC-MS/MS using ESI and ion trap MS. Two single crystals (A-5-1 and C-2-1) of the trans-isomers were obtained and determined using X-ray crystallography data, and the cis- to trans-isomerization under different conditions was discussed. Both of the cis- and trans-isomers of A-4 and A-5 exhibited good insecticidal activities against Plutella xylostella. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.