The bithorax complex (BX-C) in Drosophila is a giant cluster of closely linked genes that plays a major role in determining the segmentation pattern of the organism. From developmental and cytogenetic studies of this complex it now appears that orderly derepression of BX-C genes controls the orderly differentiation of body segments commencing with the thorax and proceeding posteriorly. The available evidence also suggests that the level of development which a given one of these segments achieves is a function of the particular subset of BX-C genes that is active in that segment. This paper summarizes the current status of our knowledge of what the BX-C genes do during development and how they are regulated. © 2007 Springer. All rights reserved.
CITATION STYLE
Lewis, E. B. (2007). Control of body segment differentiation in drosophila by the bithorax gene complex. In Genes, Development, and Cancer: The Life and Work of Edward B. Lewis (pp. 263–278). Springer Netherlands. https://doi.org/10.1007/978-1-4020-6345-9_12
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