Comparative evaluation of sodium hypochlorite, omeprazole with sodium hypochlorite and triclosan - A randomized controlled clinical trial

Abstract

Introduction: The success of endodontic treatment depends on the complete removal of microbes from the root-canal system and prevention of reinfection. The root canal is shaped with hand and rotary instruments under copious irrigation to remove the infected tissue, microbes/biofilm, and other debris from the root-canal space. Aim: The purpose of this study was to evaluate and compare the antibacterial efficacy of Omeprazole with Sodium hypochlorite, Sodium hypochlorite and Triclosan irrigation in infected root canals. Materials and Methods: In a prospective randomized clinical trial, 132 patients were selected with mean age between 18 and 60 years according to inclusion and exclusion criteria and base line scores were recorded. Based on block randomization patients were divided in to Group I 5% Sodium hypochlorite (n=44), Group II Omeprazole with 5% Sodium Hypochlorite (n=44) and Group III Triclosan (n=44). After routine root canal preparation, in Group I, Group II, Group III irrigants were delivered using endo-dontic needle inside the canal 2mm short of apex. Pre and postoperative samples were taken using paper point. Anaerobic culture has been done and number of colony forming units was counted and antibacterial efficacy was statistically analysed. Results: All the three tested irrigants showed reduction in bacterial growth but the results were not statistically significant. Conclusion: Within the limitations of this study, there is no statistical difference between the three irrigants used.