Palladium-catalyzed intramolecular aminofluorination of styrenes

Abstract

A novel palladium-catalyzed intramolecular oxidative aminofluorination of styrenes has been developed by using NFSI as fluorinating reagent. This reaction represented an efficient method for the synthesis of 2-aryl-3-fluoropyrrolidine derivatives. A novel palladium-catalyzed intramolecular aminofluorination by using NFSI as fluorinating reagent has been developed. This methodology provided a good route to synthesize 2-aryl-3-fluoropyrrolidine derivatives, albeit in a poor diastereoselectivity. © 2011 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.