Diagnostic value of urine tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 for acute kidney injury: A meta-analysis

0Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Background: Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding pro-tein-7 (IGFBP7) are both involved in renal tubular epithelial cell cycle arrest in acute kidney injury (AKI). Several recent studies showed that urine TIMP-2 times IGFBP7 ([TIMP-2]∗ [IGFBP7]) is a promising biomarker to predict AKI. Methods: The aim of this meta-analysis was to assess the diagnostic value of urine [TIMP-2]∗ [IGFBP7] for early diagnosis of AKI. Relevant studies were retrieved from the PubMed, EMBASE, and Cochrane Library databases. The sensitivity and specificity were determined, and summary receiver operating characteristic (SROC) curves were constructed. Results: Ten full-text prospective studies were included in this meta-analysis. The estimated sensitivity of urine [TIMP-2]∗[IGFBP7] for the early diagnosis of AKI was 0.84 (95% CI = 0.80-0.88) and the specificity was 0.57 (95%CI = 0.55-0.60). The SROC analysis showed an area under the curve of 0.8813. Limitation: The limited number of included studies, small sample size, unpublished negative results and language limitation might have affected the evaluation. Conclusion: Urine [TIMP-2]∗[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI. However, the potential of this biomarker should be validated in larger studies with a broader spectrum of clinical settings.

Cite

CITATION STYLE

APA

Su, Y., Gong, Z., Wu, Y., Tian, Y., & Liao, X. (2017). Diagnostic value of urine tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 for acute kidney injury: A meta-analysis. PLoS ONE, 12(1). https://doi.org/10.1371/journal.pone.0170214

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free