Asymptomatic bacteriuria in children with sickle cell anemia at the University of Nigeria teaching hospital, Enugu, South East, Nigeria

0Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Background: Urinary tract infection (UTI) is a common cause of childhood morbidity and mortality in the tropics. Children with sickle cell anemia (SCA) may have compromised kidney function arising from repeated vaso-occlusive episodes and recurrent symptomatic or asymptomatic UTI. Objectives. This study aims at determining the prevalence of asymptomatic bacteriuria and sensitivity pattern in children with homozygous sickle haemoglobin compared to children with normal haemoglobin. Methods. One hundred children with SCA in stable state and 100 children with normal haemoglobin aged 2-12 years were screened for asymptomatic bacteriuria using midstream urine samples. The samples were incubated aerobically at 37°C for 24 hours within one hour of collection. Children whose urine samples yielded significant bacteriuria (10 5cfu/ml) on two consecutive cultures were regarded as having asymptomatic bacteriuria. Results: Asymptomatic bacteriuria was noted in 6% of children with SCA and occurred more in females than males (F: M = 5:1) when compared to 2% in children with normal haemoglobin. Escherichia coli was the commonest organism isolated (33.3%). All the organisms were resistant to co-trimoxazole and ampicillin while most were sensitive to gentamicin, ceftriaxone and the quinolones. Conclusion: The risk of asymptomatic bacteriuria is three times more common in children with sickle cell anemia than in children with normal haemoglobin. It is therefore important to screen SCA patients, especially the females for UTI and should be treated according to the sensitivity result of the cultured organisms. © 2011 Chukwu et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Chukwu, B. F., Okafor, H. U., & Ikefuna, A. N. (2011). Asymptomatic bacteriuria in children with sickle cell anemia at the University of Nigeria teaching hospital, Enugu, South East, Nigeria. Italian Journal of Pediatrics. https://doi.org/10.1186/1824-7288-37-45

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free