Response to carbon dioxide after oral midazolam and pentobarbitone

Abstract

Midazolam (15 mg), pentobarbitone (100 mg) and a placebo were administered orally to nine male volunteers in double‐blind crossover studies and the effect on the ventilatory response to carbon dioxide was observed for periods of 6 hours. It was concluded that neither drug caused any significant degree of respiratory depression. Copyright © 1984, Wiley Blackwell. All rights reserved