Application of clinical prediction modeling in pediatric neurosurgery: a case study

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Abstract

There has been an increasing interest in articles reporting on clinical prediction models in pediatric neurosurgery. Clinical prediction models are mathematical equations that combine patient-related risk factors for the estimation of an individual’s risk of an outcome. If used sensibly, these evidence-based tools may help pediatric neurosurgeons in medical decision-making processes. Furthermore, they may help to communicate anticipated future events of diseases to children and their parents and facilitate shared decision-making accordingly. A basic understanding of this methodology is incumbent when developing or applying a prediction model. This paper addresses this methodology tailored to pediatric neurosurgery. For illustration, we use original pediatric data from our institution to illustrate this methodology with a case study. The developed model is however not externally validated, and clinical impact has not been assessed; therefore, the model cannot be recommended for clinical use in its current form.

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Mijderwijk, H. J., Beez, T., Hänggi, D., & Nieboer, D. (2021). Application of clinical prediction modeling in pediatric neurosurgery: a case study. Child’s Nervous System, 37(5), 1495–1504. https://doi.org/10.1007/s00381-021-05112-z

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