Long noncoding RNAs in cancer: Mechanisms of action and technological advancements

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Abstract

The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the field of cancer biology. With the current number of curated lncRNAs increasing by 10,000 in the last five years, the field is moving from annotation of lncRNA expression in various tumours to understanding their importance in the key cancer signalling networks and characteristic behaviours. Here, we summarize the previously identified as well as recently discovered mechanisms of lncRNA function and their roles in the hallmarks of cancer. Furthermore, we identify novel technologies for investigation of lncRNA properties and their function in carcinogenesis, which will be important for their translation to the clinic as novel biomarkers and therapeutic targets.

Figures

  • Fig. 1 Interest for lncRNAs (red) in the cancer scientific community compared to miRNAs (blue). The y-axis represents the number of publications and the x-axis represents time. Data was obtained by searching Pubmed for ‘lncRNA cancer’ or ‘miRNA cancer’. Data from 2016 was not used in
  • Fig. 2 Some lncRNAs associated with cancers. The colour represents either upregulated (red) or downregulated (blue) compared to normal tissues

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CITATION STYLE

APA

Bartonicek, N., Maag, J. L. V., & Dinger, M. E. (2016, May 27). Long noncoding RNAs in cancer: Mechanisms of action and technological advancements. Molecular Cancer. BioMed Central Ltd. https://doi.org/10.1186/s12943-016-0530-6

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