Abstract
Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim- sulfamethoxazole by oral administration. ZDV areas under the concentration- time curves were (means ± standard deviations) 1.80 ± 0.70 and 1.69 ± 0.64 μg · h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 ± 0.61 and 1.74 ± 0.66 liters/h/kg, respectively.
Cite
CITATION STYLE
Cañas, E., Pachon, J., Garcia-Pesquera, F., Castillo, J. R., Viciana, P., Cisneros, J. M., & Jimenez-Mejias, M. E. (1996). Absence of effect of trimethoprim-sulfamethoxazole on pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus. Antimicrobial Agents and Chemotherapy, 40(1), 230–233. https://doi.org/10.1128/aac.40.1.230
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
