The Ketogenic Diet: Proposed Mechanisms of Action

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Abstract

The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis. © 2009.

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Nylen, K., Likhodii, S., & Burnham, W. M. I. (2009). The Ketogenic Diet: Proposed Mechanisms of Action. Neurotherapeutics, 6(2), 402–405. https://doi.org/10.1016/j.nurt.2009.01.021

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