Abstract
In this prospective study, we examined the pharmacokinetics of 1 and 2 mg/kg liposomal amphotericin B in 16 morbidly obese individuals (104-177 kg). Body size had no effect on clearance. We recommend a fixed dose in patients ≥100 kg (ie, 300 or 500 mg rather than the current dose of 3 and 5 mg/kg, respectively).
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Wasmann, R. E., Smit, C., van Dongen, E. P. H., Wiezer, R. M. J., Adler-Moore, J., de Beer, Y. M., … Brüggemann, R. J. M. (2020). Fixed dosing of liposomal amphotericin b in morbidly obese individuals. Clinical Infectious Diseases, 70(10), 2213–2215. https://doi.org/10.1093/cid/ciz885
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