Rare inherited diseases and vitiligo

Abstract

Core Messages: Some monogenic disorders such as piebald-ism have marked phenotypic overlap with viti-ligo, which raise the question of a common pathogenic background. Another interesting point of monogenic diseases, which include organ-specific autoim-munity, is the use of the monogenic disease as a model to identify autoantigens of importance in vitiligo. Auto-immune polyendocrine syndromes, mitochondrial, and breakage disorders can be associated with a vitiligo phenotype. © 2010 Springer-Verlag Berlin Heidelberg.