Abstract
This double-blind crossover clinical trial randomized 12 adult males to receive 200 mg of caffeine from a green coffee extract, a guayusa leaf extract, and a synthetic control to compare their safety, absorption, and effect on neurotransmitters. The results showed no statistically significant changes in blood pressure or heart rate from baseline to 120 min postdose of each natural source compared with changes from baseline in the control (0.094 < = P
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CITATION STYLE
Krieger, D. R., Kalman, D. S., Feldman, S., Arnillas, L., Goldberg, D., Gisbert, O., & Nader, S. (2016). The Safety, Pharmacokinetics, and Nervous System Effects of Two Natural Sources of Caffeine in Healthy Adult Males. Clinical and Translational Science, 9(5), 246–251. https://doi.org/10.1111/cts.12403
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