Urine could be a convenient source of biomarkers for different diseases and clinical applications, mostly for cancer diagnosis, prognosis, treatment monitoring, and prenatal diagnosis. The ultra-noninvasive sampling and the possibility to analyze large volume are the main undisputed advantages of urine-based protocols. Recent and comprehensive studies showed that urinary cell-free DNA (ucfDNA) is informative to identify the genomic signature of patients, resulting in a huge tool to track the tumor evolution and for personalized medicine in urological and non-urological cancer. In this chapter, we reported the main published evidences on ucfDNA, with the aim at discussing its promising and translatable role in clinical practices.
CITATION STYLE
Salvi, S., & Casadio, V. (2019). Urinary cell-free DNA: Potential and applications. In Methods in Molecular Biology (Vol. 1909, pp. 201–209). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8973-7_15
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