Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision

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Abstract

Unimodal sensory loss leads to structural and functional changes in both deprived and nondeprived brain circuits. This process is broadly known as cross-modal plasticity. The evidence available indicates that cross-modal changes underlie the enhanced performances of the spared sensory modalities in deprived subjects. Sensory experience is a fundamental driver of cross-modal plasticity, yet there is evidence from early-visually deprived models supporting an additional role for experience-independent factors. These experience-independent factors are expected to act early in development and constrain neuronal plasticity at later stages. Here we review the cross-modal adaptations elicited by congenital or induced visual deprivation prior to vision. In most of these studies, cross-modal adaptations have been addressed at the structural and functional levels. Here, we also appraise recent data regarding behavioral performance in early-visually deprived models. However, further research is needed to explore how circuit reorganization affects their function and what brings about enhanced behavioral performance.

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APA

López-Bendito, G., Aníbal-Martínez, M., & Martini, F. J. (2022, July 1). Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision. Annual Review of Neuroscience. Annual Reviews Inc. https://doi.org/10.1146/annurev-neuro-111020-104222

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