CD4+ T-cells are required for the establishment of maedi-visna virus infection in macrophages but not dendritic cells in vivo

25Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

The role of CD4+ lymphocytes in the establishment of lentivirus infection in macrophages has been studied in an in vivo system of lentivirus infection where CD4+ lymphocytes are not the targets for infection. Using the non-T-cell-tropic lentivirus, maedi-visna virus (MVV), in CD4-depleted sheep, we have found that CD4+ T cells were required for MW infection in macrophages but not dendritic cells. CD4-depleted sheep had significantly lower levels of MW-infected cells in lymph nodes and efferent lymph after MW challenge in the drainage area of the lymph node. Due to the absence of virus in combination with the lack of CD4+ T helper cells, virus-specific immune responses were reduced. There was delayed induction of cytotoxic T cell precursors, a marked reduction in virus-specific in vitro proliferative responses, and a delay in the appearance of MW-specific antibodies. By contrast, CD4 depletion had no effect on the establishment of MW infection in afferent lymph dendritic cells migrating from the skin infection site to the lymph node.

Cite

CITATION STYLE

APA

Eriksson, K., McInnes, E., Ryan, S., Tonks, P., McConnell, I., & Blacklaws, B. (1999). CD4+ T-cells are required for the establishment of maedi-visna virus infection in macrophages but not dendritic cells in vivo. Virology, 258(2), 355–364. https://doi.org/10.1006/viro.1999.9711

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free