Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2)

Abstract

Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas V12 can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas V12. These observations indicate that Paip2 is able to function as a tumor suppressor. © 2011 forenameinitialRosenfeld.