Abstract
Three clerodane diterpenoids, 8S-kolavic acid 18-methyl ester (1), 8S-kolavic acid 15-methyl ester (2) and 8S-kolavenol (3) were isolated from the acetone extract of the stem bark of Entada abyssinica along with trans-communic acid (4) and 1-octacosanol. Their structures were established mainly based on 1D (1H, 13C and DEPT) and 2D (1H-1H COSY, HSQC and HMBC) NMR experiments. Compound 1, described here for the first time, showed strong antimicrobial and moderate antileishmanial activities.
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Tchinda, A. T., Fuendjiep, V., Mekonnen, Y., Ngo, B. B., & Dagne, E. (2007). A bioactive diterpene from Entada abyssinica. Natural Product Communications, 2(1), 9–12. https://doi.org/10.1177/1934578x0700200103
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