Risk Assessment of Short-Chain Chlorinated Paraffins in Japan

Abstract

The objective of this chapter is to assess the ecological and human health risk of short-chain chlorinated paraffins (SCCPs) via the environment in Japan First, release sources of SCCPs are identified based on the substance flow analysis, and the volume of their releases is estimated. Next, the behavior of SCCPs in the environment is estimated using a multimedia model, and the estimated SCCPs concentrations in the environment and food are validated with measured concentrations. Then, the endpoints and doses of SCCPs as the criteria for ecological and human health risk assessment are derived through the review of the existing toxicological data. Finally, risk characterization is performed based on the results of exposure assessment and dose-response assessment. As a result, it is determined that there is little need to be concerned about potential ecological risk to aquatic, sediment-dwelling, and soil-dwelling organisms in local areas and the regions in Japan. As far as human health risk is concerned, the Margins of exposure are 1.5 x 10(5) and 2.2 x 10(6), which are larger than uncertainty factors. Thus, it is determined that there is no significant human health risk via the environment