Protein therapeutic: Production, application, and future scenario

Abstract

The demands for recombinant therapeutic proteins are escalating rapidly over the past two decades because of its effectiveness in treating human diseases that are uncurable. To meet the increasing demand, there is continuous need to enhance the existing expression systems, furthermore building up an attractive strategy to confront the therapeutic protein demands. Nowadays, human cell line has come up as a novel and effective strategy to generate therapeutic proteins since this expression framework possesses the machinery to modify the recombinant proteins to its final form (posttranslational modifications) analogous to those present human proteins. In addition human cell lines also decrease the possible immunogenicity against non-human antigenic determinants. Therefore, the present chapter discusses about how recombinant proteins with therapeutic properties can be in mammalian cells and their application, and finally we will talk how new innovations might add to the further advancement and generation of therapeutic proteins.