Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials

24Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Testosterone treatment increases erythrocytes in men, but its effects on leukocyte and platelet counts are unknown and could affect its safety. Objective: To determine whether testosterone affects circulating leukocytes and platelets in men. Methods: Secondary analyses of two randomized testosterone trials were performed: the 5α-reductase (5aR) and OPTIMEN trials. In 5aR trial, 102 healthy men, 21-50 years (mean age 38), received a long-acting GnRH agonist, and 50, 125, 300, or 600 mg/week testosterone enanthate (TE) plus placebo or 2.5 mg/day dutasteride for 20 weeks. In OPTIMEN, 78 functionally limited men, ≥65 years (mean age 72) with protein intake ≤ 0.83 g kg−1 day−1, were randomized to controlled diets with 0.8 g kg−1 day−1 protein or 1.3 g kg−1 day−1 protein plus placebo or TE (100 mg/week) for 6 months. Changes from baseline in total and differential leukocyte count, and platelet count were evaluated. Results: In 5aR, testosterone administration was associated with increases in total leukocyte (estimated change from baseline 40, 490, 1230, and 1280 cells/µL, P

Cite

CITATION STYLE

APA

Gagliano-Jucá, T., Pencina, K. M., Guo, W., Li, Z., Huang, G., Basaria, S., & Bhasin, S. (2020). Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials. Andrology, 8(5), 1324–1331. https://doi.org/10.1111/andr.12834

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free