Correlation of D-Dimer Level with Severity of Pneumonia, Hospital Stay and Mortality in Case of Covid-19 Infection: A Retrospective Study an a Tertiary Care Hospital.

Abstract

Introduction: Worldwide there was a pandemic of novel corona virus infection in which one of the major concern was therisk of thrombosis and the mortality associated with it.Aim: In this study our aim was to observe the changes in D-dimer levels during disease progression and its correlationswith severity of Pneumonia, duration of hospital stay and mortality of COVID-19 patients.Materials & Methods: In this study we reported the clinical, radiological and pathological laboratory results of 432 casesof confirmed COVID-19 infection. In these patients their clinical presentation, concentration of D-dimer, coagulationparameters, CBC, severity of Pneumonia on HRCT, hospital stay and higher mortality were retrospectively analyzed.Result: All the statistical variables were expressed in % and compared withx2 test. Out of the 432 cases in 45 cases (10.41%)the D-dimer values were >2.4μg/ml and in 15 cases the value were very high (3.47%). When correlated these patientsfound to have severe degree of pneumonia, longer hospital stay and higher mortality rate in comparison to patients withD-dimer level of <2.4 μg/ml.Conclusion: D-dimer level could be used as an early marker for the clinical classification, risk stratification and improvedmanagement of COVID-19 patients.