Older candidates for subthalamic deep brain stimulation in Parkinson's disease have a higher incidence of psychiatric serious adverse events

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Abstract

Objective: To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). Methods: We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. Results: A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). Conclusions: The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.

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Cozac, V. V., Ehrensperger, M. M., Gschwandtner, U., Hatz, F., Meyer, A., Monsch, A. U., … Fuhr, P. (2016). Older candidates for subthalamic deep brain stimulation in Parkinson’s disease have a higher incidence of psychiatric serious adverse events. Frontiers in Aging Neuroscience, 8(JUN). https://doi.org/10.3389/fnagi.2016.00132

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