Wound healing activity of skin incision and skin burn from spray gel formula contains combination of banana stem (Musa acuminata Colla) and Aloe vera ethanol extracts on mice

Abstract

Various studies reports the activity of wound healing from banana stem (Musa species) and also Aloe vera individually. This research purpose are to identify the wound healing activity of skin incision and skin burn animal model from spray gel formula contains combination of Musa paradisiaca Colla and Aloe vera L ethanol extracts on mice. This research were used randomized post test only control group design. Each of incision wound and burn wound models were used 28 mice and divided into 7 group. Group I was given with banana stem extract (BSE) 10%. Group II was given with Aloe vera extract (AVE) 10%. Group III was given with 7,5% BSE and 2,5% AVE. Group IV was given with 5% BSE and 5% AVE. Group V was given with 2,5% BSE and 7,5% AVE. Group VI and group VII (povidone iodine) as vehicle and positive control respectively. All group were sprayed twice a day from first day until seventh day after skin incision/burn induction, and length of wound/wound diameter were observed everyday. The result showed that combination of BSE and AVE had wound healing activity in both wound model which did not different significantly compared with individual extract.