Antimycoplasmal activities of the speudomonic acids and structure-activity relationships of monic acid A derivatives

Abstract

The antimycoplasmal activities of the pseudomonic acids isolated from Pseudomonas fluorescens NCIB 10586 are reported. Structure-activity relationships of a variety of ester, amide and thiol ester derivatives of the nucleus, monic acid A, are described. Enhanced antimycoplasmal activity is reported for a number of monic acid A esters and the most potent derivative, m-nitrobenzyl monate A, is a 100-fold more active against Mycoplasma hyopneu-moniae than pseudomonic acid A. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.