Combined interleukin-12 and topical chemotherapy for established leishmaniasis drastically reduces tissue parasitism and relapses in susceptible mice

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Abstract

The efficacy of the association of paromomycin sulfate (PA) with recombinant (r) interleukin (IL)-12 was investigated by topical treatment of BALB/c mice infected with Leishmania major that displayed fully developed cutaneous lesions. Although healing was observed in PA-treated groups, lesions recurred in 100% of these animals 70 days after treatment. In contrast, lesions were absent in a high proportion of PA- and rIL-12 - treated mice 120 days after treatment. The PA/rIL-12 - treated mice had a switch in cytokine response, from high IL-4 and low interferon (IFN) - γ levels to low IL-4 and high IFN-γ levels, and reductions in parasite load, dissemination of parasites, and inflammation. Thus, the association of rIL-12 to topical chemotherapy for leishmaniasis may be an important strategy for increasing cure rates and decreasing the incidence of relapse.

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Fernandes, A. P., Carvalho, F. A. A., Tavares, C. A. P., Santiago, H. C., Castro, G. A., Tafuri, W. L., … Gazzinelli, R. T. (2001). Combined interleukin-12 and topical chemotherapy for established leishmaniasis drastically reduces tissue parasitism and relapses in susceptible mice. Journal of Infectious Diseases, 183(11), 1646–1652. https://doi.org/10.1086/320699

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