Restoring stem cells-all you need is NAD+

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Abstract

The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD-raising compound, can rejuvenate stem cells and extend lifespan in mice.

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Wu, L. E., & Sinclair, D. A. (2016, September 1). Restoring stem cells-all you need is NAD+. Cell Research. Nature Publishing Group. https://doi.org/10.1038/cr.2016.80

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