Background: Cortical and subcortical cognitive impairments are usually found in dementia with Lewy bodies (DLB). Roughly, they comprise visuo-constructive/executive function and attention/processing speed impairments, whereas memory would remain relatively spared. In this study, we focused on the neuro-anatomical substrates of attention and processing speed, which is still poorly understood. For the purpose of the study, we examined the correlations between behavioral scores measuring the speed of processing and the degree of cerebral atrophy in patients with prodromal to moderate DLB. Methods: Ninety-three prodromal to moderate DLB patients (mean MMSE = 25.5) were selected to participate in the study as well as 28 healthy elderly subjects (mean MMSE = 28.9), matched in terms of age and educational level. The Trail Making Test A (TMTA) and the Digit Symbol Substitution Test (DSST) were used to assess attention and processing speed. Behavioral performances were compared between patients and healthy control subjects. Three-dimensional MRI images were acquired for all participants, and correlational analyses were performed in the patient group using voxel-based morphometry (VBM). Results: The behavioral results on both the TMTA (p =.026) and the DSST (p
CITATION STYLE
Botzung, A., Philippi, N., Noblet, V., Loureiro De Sousa, P., & Blanc, F. (2019). Pay attention to the basal ganglia: A volumetric study in early dementia with Lewy bodies. Alzheimer’s Research and Therapy, 11(1). https://doi.org/10.1186/s13195-019-0568-y
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