In vitro susceptibility of Aspergillus spp. clinical isolates to albendazole

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Abstract

The in vitro antifungal activity of albendazole, a benzimidazole widely used as an antihelmintic drug in humans, was investigated and assessed for its activity against Aspergillus spp. Forty-eight isolates, representing the most frequent species found in human pathology [Aspergillus fumigatus (n = 27), Aspergillus flavus (n = 10), Aspergillus terreus (n = 7), Aspergillus nidulans (n = 3) and Aspergillus niger (n = 1)], and one quality control strain (A. niger ATCC 9804 83435) were tested according to the NCCLS M38-P methodology for moulds. All the strains were susceptible to albendazole, with homogeneous MICs for each species; three strains were resistant to itraconazole.

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Berthet, N., Faure, O., Bakri, A., Ambroise-Thomas, P., Grillot, R., & Brugère, J. F. (2003). In vitro susceptibility of Aspergillus spp. clinical isolates to albendazole. Journal of Antimicrobial Chemotherapy, 51(6), 1419–1422. https://doi.org/10.1093/jac/dkg245

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